Go through the following statement:-
(i) In both pre-pubertal and post-meno-pausal females, there are low levels of female sex hormones and high levels of gonadotrophins.
(ii) There is no bleeding in an oestrous cycle as the broken endometrium is absorbed.
(iii) Oestrogen is mainly secreted by the granulosa cells and progesterone mainly by the theca cells
(iv) Some of the menopausal symptoms can be reversed HRT wherein a small sode of gonadotrophins is given to the patient.
Which of these are correct?

Options

A. (ii) & (iii)
B. (i), (ii), (iv)
C. (i), (ii) & (iii)
D. All are correct

Answer

To determine which statements are correct regarding human reproduction, let's analyze each statement one by one:

### Step-by-Step Solution:

1. **Statement (i)**: "In both pre-pubertal and post-menopausal females, there are low levels of female sex hormones and high levels of gonadotrophins."
- **Analysis**: This statement is incorrect. In pre-pubertal females, the levels of female sex hormones (like estrogen and progesterone) are low, but gonadotrophins (LH and FSH) are also low. In post-menopausal females, there are low levels of female sex hormones, but gonadotrophins are elevated due to the lack of feedback inhibition from the ovaries. Therefore, this statement is false.

2. **Statement (ii)**: "There is no bleeding in an oestrous cycle as the broken endometrium is absorbed."
- **Analysis**: This statement is correct. In an oestrous cycle, the endometrium does not shed in the same way as in the menstrual cycle. Instead, any breakdown of the endometrium is reabsorbed, leading to no external bleeding. Thus, this statement is true.

3. **Statement (iii)**: "Oestrogen is mainly secreted by the granulosa cells and progesterone mainly by the theca cells."
- **Analysis**: This statement is also correct. Oestrogen is primarily produced by the granulosa cells of the ovarian follicles, while progesterone is mainly secreted by the theca cells after ovulation when the follicle transforms into the corpus luteum. Therefore, this statement is true.

4. **Statement (iv)**: "Some of the menopausal symptoms can be reversed HRT wherein a small dose of gonadotrophins is given to the patient."
- **Analysis**: This statement is incorrect. Hormone Replacement Therapy (HRT) for menopausal symptoms typically involves estrogen and progesterone, not gonadotrophins. Therefore, this statement is false.

### Conclusion:
Based on the analysis:
- Statement (ii) is true.
- Statement (iii) is true.
- Statements (i) and (iv) are false.

Thus, the correct statements are **(ii) and (iii)**.

### Final Answer:
The correct statements are **(ii) and (iii)**.

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