In DNA model of Watson & Crick, the major grooves are site of

Options

A. binding of histone proteins
B. binding of acidic proteins
C. binding of RNA molecules
D. binding of glycoproteins

Answer

**Step-by-Step Solution:**

1. **Understanding the DNA Structure**: The DNA model proposed by Watson and Crick is a double helix structure. It consists of two strands that run in opposite directions, known as antiparallel strands. Each strand has a 5' end and a 3' end.

2. **Identifying Major and Minor Grooves**: In the DNA double helix, there are two types of grooves formed due to the twisting of the strands: the major groove and the minor groove. The major groove is wider (approximately 22 angstroms) compared to the minor groove (approximately 12 angstroms).

3. **Function of the Major Groove**: The major groove is significant because it provides a larger surface area for protein binding. This allows proteins to interact with the DNA more effectively.

4. **Binding Sites**: The question asks about what binds to the major groove. The options given are:
- Binding of histone proteins
- Binding of acidic proteins
- Binding of RNA molecules
- Binding of glycoproteins

5. **Analyzing the Options**:
- Histone proteins primarily bind to the DNA at specific sites, but they are more associated with the overall structure of chromatin rather than specifically binding at the major groove.
- Acidic proteins, on the other hand, often interact with the major groove due to the accessibility and the larger area it provides for binding.
- RNA molecules can interact with DNA, but they do not specifically bind to the major groove.
- Glycoproteins are typically involved in cell signaling and recognition rather than direct binding to the major groove of DNA.

6. **Conclusion**: Given that the major groove allows for easier access and binding of proteins, the correct answer is that the major grooves are the sites for the binding of acidic proteins.

**Final Answer**: The correct answer is **binding of acidic proteins**.

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