Which of the following biomolecules does have a phosphodiester bond ?

Options

A. Fatty acids
B. Monosaccharides
C. amino acids
D. Nucleic acids

Explanation

To determine which biomolecule contains a phosphodiester bond, we can follow these steps:

### Step-by-Step Solution:

1. **Identify the Biomolecules**: The options given are fatty acids, monosaccharides, amino acids, and nucleic acids.

2. **Understand the Structure of Each Biomolecule**:
- **Fatty Acids**: These are long hydrocarbon chains with a carboxylic acid group. They do not contain phosphodiester bonds.
- **Monosaccharides**: These are simple sugars like glucose and fructose. They are linked by glycosidic bonds, not phosphodiester bonds.
- **Amino Acids**: These are the building blocks of proteins and are linked by peptide bonds. They do not contain phosphodiester bonds.
- **Nucleic Acids**: These include DNA and RNA, which are polymers made up of nucleotide units.

3. **Focus on Nucleic Acids**: Nucleic acids are composed of chains of nucleotides. Each nucleotide consists of a sugar, a phosphate group, and a nitrogenous base.

4. **Identify the Bond in Nucleic Acids**: In nucleic acids, the nucleotides are linked together by phosphodiester bonds. This bond forms between the 3' carbon atom of one sugar molecule and the 5' carbon atom of the next sugar molecule, creating a backbone for the nucleic acid strand.

5. **Conclusion**: Since nucleic acids are the only biomolecules listed that contain phosphodiester bonds, the answer to the question is **nucleic acids**.

### Final Answer:
**Nucleic Acids** contain phosphodiester bonds.

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