Which one of the following pairs is mis - matched ?

Options

A. Hypocortisolism - Cretinism
B. Hypothyroidism - Myxoedema
C. Hypercortisolism - Cushing's syndrome
D. Hyperthyroidism - Exophthalmic goitre

Answer

To determine which pair is mismatched, we need to analyze each option provided in the question:

1. **Hypocortisolism - Cretinism**:
- Hypocortisolism refers to a deficiency of cortisol, which is produced by the adrenal glands. The condition associated with hypocortisolism is Addison's disease, not cretinism. Cretinism is a result of hypothyroidism, specifically due to a deficiency of thyroid hormones. Therefore, this pair is mismatched.

2. **Hypothyroidism - Myxedema**:
- Hypothyroidism is a condition where there is insufficient production of thyroid hormones. Myxedema is indeed a severe form of hypothyroidism, characterized by swelling and other symptoms due to low thyroid hormone levels. This pair is correctly matched.

3. **Hypercortisolism - Cushing's Syndrome**:
- Hypercortisolism refers to an excess of cortisol, and Cushing's syndrome is a condition that results from this excess. It can be caused by various factors, including tumors or prolonged use of corticosteroid medications. This pair is correctly matched.

4. **Hyperthyroidism - Exophthalmic Goiter**:
- Hyperthyroidism is characterized by an overproduction of thyroid hormones, and exophthalmic goiter (also known as Graves' disease) is a specific type of hyperthyroidism that causes bulging eyes due to swelling of the tissues behind the eyes. This pair is correctly matched.

Based on this analysis, the mismatched pair is:

**Answer**: Hypocortisolism - Cretinism