Phenylketonuria, Huntington's disease and sickle-cell anaemia are caused respectively due to disorders associated with

Options

A. chromosome 7,11,12
B. chromosome 11,4,12
C. chromosome 4,7,11
D. chromosome 12,4,11

Answer

To solve the question regarding the genetic disorders Phenylketonuria, Huntington's disease, and sickle-cell anemia, we need to identify the chromosomes associated with each condition.

### Step-by-Step Solution:

1. **Identify Phenylketonuria (PKU)**:
- Phenylketonuria is caused by a mutation in the PAH gene, which is responsible for the metabolism of the amino acid phenylalanine.
- This gene is located on **chromosome 12**.

2. **Identify Huntington's Disease**:
- Huntington's disease is an autosomal dominant disorder caused by a mutation in the HTT gene.
- This gene is located on **chromosome 4**.

3. **Identify Sickle-Cell Anemia**:
- Sickle-cell anemia is caused by a mutation in the HBB gene, which encodes the beta-globin subunit of hemoglobin.
- This gene is located on **chromosome 11**.

4. **Compile the Findings**:
- Phenylketonuria - Chromosome 12
- Huntington's Disease - Chromosome 4
- Sickle-Cell Anemia - Chromosome 11

5. **Match with Given Options**:
- The correct order of chromosomes associated with the disorders is:
- Phenylketonuria (12), Huntington's Disease (4), Sickle-Cell Anemia (11).
- Therefore, the correct option is **D: Chromosome 12, 4, and 11**.

### Final Answer:
The disorders are caused respectively due to disorders associated with **Chromosome 12, 4, and 11**.

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