Consider the following nucleic acids 1. DNA, 2. r-RNA, 3. t-RNA, 4. m-RNA choose the correct sequence of their arrangement according to their participation in protein synthesis

Options

A. 1,2,3,4
B. 2,3,4,1
C. 3,2,1,4
D. 1,4,2,3

Answer

To determine the correct sequence of nucleic acids according to their participation in protein synthesis, we need to understand the roles of each type of nucleic acid involved in the process.

### Step-by-Step Solution:

1. **Identify the Role of DNA**:
- DNA (Deoxyribonucleic Acid) is the genetic material that contains the instructions for protein synthesis. The process begins with DNA, which serves as the template for the synthesis of mRNA through transcription.
- **Hint**: Think of DNA as the blueprint for building proteins.

2. **Formation of mRNA**:
- The first step in protein synthesis is transcription, where the information in DNA is transcribed to form messenger RNA (mRNA). This mRNA carries the genetic code from the DNA to the ribosome, where proteins are synthesized.
- **Hint**: mRNA is like a messenger that carries the instructions from DNA to the site of protein synthesis.

3. **Role of rRNA**:
- Ribosomal RNA (rRNA) is a component of ribosomes, which are the sites of protein synthesis. The mRNA binds to the rRNA in the ribosome, allowing the translation process to occur.
- **Hint**: rRNA acts as the machinery that facilitates the translation of mRNA into a protein.

4. **Role of tRNA**:
- Transfer RNA (tRNA) is responsible for bringing the appropriate amino acids to the ribosome during translation. Each tRNA has an anticodon that pairs with the corresponding codon on the mRNA, ensuring that the correct amino acid is added to the growing polypeptide chain.
- **Hint**: tRNA is like a delivery truck that brings amino acids to the assembly line (ribosome).

5. **Sequence of Participation**:
- Based on the roles identified:
- First, DNA is transcribed into mRNA.
- Second, mRNA interacts with rRNA at the ribosome.
- Third, tRNA brings amino acids to the ribosome to build the protein.
- Therefore, the correct sequence according to their participation in protein synthesis is:
1. DNA (1)
2. mRNA (4)
3. rRNA (2)
4. tRNA (3)

6. **Final Arrangement**:
- The correct order is 1 (DNA), 4 (mRNA), 2 (rRNA), 3 (tRNA), which corresponds to option D: 1 4 2 3.

### Conclusion:
The correct sequence of nucleic acids according to their participation in protein synthesis is **1 (DNA), 4 (mRNA), 2 (rRNA), 3 (tRNA)**, which corresponds to option D.