There is some permissible latitude in the pairing of the third base in the codon. This is

Options

A. wobble hypothesiis
B. Lyon's hypothesis
C. Khorana's phyothesis
D. Watson's hypthesis

Answer

### Step-by-Step Solution:

1. **Understanding Codons and Anticodons**:
- Codons are sequences of three nucleotides in mRNA that correspond to specific amino acids during protein synthesis.
- Anticodons are sequences of three nucleotides in tRNA that are complementary to the codons in mRNA.

2. **Explaining the Base Pairing**:
- During translation, the pairing between the codon in mRNA and the anticodon in tRNA is crucial for the correct incorporation of amino acids into the growing polypeptide chain.

3. **Introducing Wobble Hypothesis**:
- The "wobble hypothesis" refers to the flexibility in the base pairing at the third position of the codon. This means that the third base can pair with more than one type of base in the anticodon, allowing for some variability in the genetic code.

4. **Codon Degeneracy**:
- Due to this wobble pairing, multiple codons can code for the same amino acid. This phenomenon is known as codon degeneracy, which helps to minimize the effects of mutations.

5. **Evaluating Other Hypotheses**:
- The question also mentions other hypotheses:
- **Leon Hypothesis**: Relates to gene dosage compensation, not codon pairing.
- **Koran Hypothesis**: Incorrectly states that three codons always code for one amino acid without considering wobble.
- **Watson Hypothesis**: Pertains to the structure of DNA, not codon-anticodon interactions.

6. **Conclusion**:
- The correct answer to the question is the "wobble hypothesis," as it specifically addresses the permissible latitude in the pairing of the third base in the codon.

### Final Answer:
The permissible latitude in the pairing of the third base in the codon is explained by the **wobble hypothesis**.

---