During transcription holoenzyme RNA polymerase binds to a DNA sequence and the DNA assumes a saddle like structure at that point. What is that sequence called ?

Options

A. AATT
B. CACC
C. TATA
D. TTAA

Answer

To solve the question regarding the DNA sequence where the holoenzyme RNA polymerase binds during transcription, we can follow these steps:

### Step-by-Step Solution:

1. **Understanding the Context**:
- During transcription, RNA polymerase binds to specific sequences on the DNA to initiate the process of synthesizing RNA from the DNA template.

2. **Identifying the Sequence**:
- The question mentions that the DNA assumes a "saddle-like" structure at the binding point of the RNA polymerase. This description is characteristic of a specific DNA sequence known as the TATA box.

3. **Recognizing the TATA Box**:
- The TATA box is a conserved sequence found in many eukaryotic promoters. It typically consists of the sequence TATAAA and is located about 25 to 35 base pairs upstream of the transcription start site.

4. **Function of the TATA Box**:
- The TATA box plays a crucial role in the initiation of transcription. It serves as a binding site for transcription factors, including the TATA-binding protein (TBP), which helps to recruit RNA polymerase to the promoter region.

5. **Conclusion**:
- Based on the information provided and the characteristics of the sequences given in the options, the correct answer to the question is **TATA** (option C).

### Final Answer:
The sequence where the holoenzyme RNA polymerase binds during transcription is called the **TATA box**.

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