Which of the following are the reason(s) for Rheumatoid arthritis? Choose the correct option.
(i) Lymphocytes becomes more active
(ii) Body attacks self cells
(iii) More antibodies are produced in the body
(iv) The ability to differentiate pathogens or foreign molecules from self cells is lost

Options

A. i and ii
B. ii and iv
C. iii and iv
D. i and iii

Answer

To solve the question regarding the reasons for Rheumatoid arthritis, we will analyze each statement provided in the options.

### Step 1: Analyze the Statements
1. **Statement (i): Lymphocytes become more active.**
- In Rheumatoid arthritis, the immune system is dysregulated, leading to increased activity of lymphocytes. This is a correct statement.

2. **Statement (ii): Body attacks self cells.**
- Rheumatoid arthritis is an autoimmune disease where the body's immune system mistakenly attacks its own cells, particularly in the joints. This statement is also correct.

3. **Statement (iii): More antibodies are produced in the body.**
- While antibodies may be involved in the disease process, the primary issue in Rheumatoid arthritis is not simply the quantity of antibodies produced but rather the misdirected immune response. This statement is not necessarily correct in the context of the primary causes of the disease.

4. **Statement (iv): The ability to differentiate pathogens or foreign molecules from self cells is lost.**
- This statement is true as well. In autoimmune diseases like Rheumatoid arthritis, the immune system loses the ability to distinguish between self and non-self, leading to the attack on the body's own tissues.

### Step 2: Identify the Correct Options
Based on the analysis:
- Statements (i) and (ii) are correct.
- Statement (iii) is not a primary reason for Rheumatoid arthritis.
- Statement (iv) is also correct.

### Conclusion
The correct option that includes the reasons for Rheumatoid arthritis is:
- **Option: First and Second (i and ii)**