Anaphase promoting complex (APC) is a protein degradation machinery necessary for proper mitosis of animal cells. If APC is defective in a human cell, which of the following is expected to occur

Options

A. Chromosomes will not condense
B. Chromosomes will be fragmented
C. Chromosomes will not segregate
D. Recombination of chromosome arms will occur

Explanation

**Step-by-Step Solution:**

1. **Understanding the Role of APC**: The Anaphase Promoting Complex (APC) is crucial for the progression of mitosis, specifically during the anaphase stage. Its primary function is to facilitate the separation of sister chromatids by promoting the degradation of proteins that hold them together.

2. **Defect in APC**: If the APC is defective, it cannot effectively promote the degradation of these proteins, particularly cohesin, which is responsible for keeping sister chromatids attached to one another.

3. **Consequences of APC Defect**: Due to the inability of APC to function properly, the cohesin proteins will not be degraded. As a result, the sister chromatids will remain attached, preventing their separation.

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