Thalassemia and sickle cell anemia are caused due to a problem in globin molecule synthesis. Select the correct statement

Options

A. Both are due to a qualitative defect in globin chain synthesis
B. Both are due to a quantitative defect in globin chain synthesis.
C. Thalassemia is due to less synthesis of globin molecules.
D. Sickle cell anemia is due to a quantitative problem of globin molecules

Explanation

To solve the question regarding thalassemia and sickle cell anemia, we need to analyze the nature of these two conditions in relation to globin molecule synthesis. Here’s a step-by-step breakdown:

### Step 1: Understand Sickle Cell Anemia
- Sickle cell anemia is caused by a point mutation in the gene that encodes for the beta-globin chain of hemoglobin.
- This mutation results in the production of an abnormal form of hemoglobin known as hemoglobin S (HbS), which causes red blood cells to become rigid and sickle-shaped.
- Since this mutation affects the quality of the globin produced, sickle cell anemia is classified as a **qualitative defect** in globin chain synthesis.

**Hint:** Look for mutations that affect the structure of proteins; these often lead to qualitative defects.
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