Noble prize of 1978 for restriction endonuclease technology was given to :

Options

A. Temin and Baltimore
B. Milstein and Kohler
C. Arber, Nathans and Smith
D. Holley, Khorana and Nirenberg

Answer

**Step-by-Step Solution:**

1. **Understanding the Question**: The question asks about the recipients of the Nobel Prize in 1978 specifically for their work related to restriction endonuclease technology.

2. **Identifying the Candidates**: The candidates mentioned are:
- A) Temin and Baltimore
- B) Kohler and Milstein
- C) Arber, Nathans, and Smith
- D) Hole, Khurana, and Nirenberg

3. **Analyzing Each Option**:
- **Option A**: Temin and Baltimore were awarded the Nobel Prize in 1975 for their work on reverse transcriptase, not restriction endonucleases.
- **Option B**: Kohler and Milstein received the Nobel Prize in 1984 for developing hybridoma technology for monoclonal antibodies, which is unrelated to restriction endonucleases.
- **Option C**: Arber, Nathans, and Smith were awarded the Nobel Prize in 1978 for their discovery of restriction enzymes, which are crucial for molecular genetics and DNA manipulation.
- **Option D**: Hole, Khurana, and Nirenberg were awarded the Nobel Prize in 1968 for their work on the genetic code and protein synthesis, not for restriction endonucleases.

4. **Conclusion**: The correct answer is **C) Arber, Nathans, and Smith**, as they were the ones who received the Nobel Prize in 1978 for their work on restriction endonucleases.

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