DNA content is doubled during

Options

A. metaphase
B. interphase
C. prophase
D. telophase

Answer

**Step-by-Step Solution:**

1. **Understanding the Question**: The question asks during which phase of the cell cycle the DNA content is doubled. The options given are metaphase, interphase, prophase, and telophase.

2. **Analyzing Each Phase**:
- **Metaphase**: This phase is characterized by the alignment of chromosomes at the metaphase plate. There is no doubling of DNA during this phase.
- **Interphase**: This is the phase where the cell prepares for division. It consists of three sub-phases: G1 (cell growth), S (synthesis where DNA is replicated), and G2 (preparation for mitosis). The key event here is that the DNA content is doubled during the S phase.
- **Prophase**: During prophase, the chromatin condenses into visible chromosomes. This is primarily a phase of DNA condensation, not doubling.
- **Telophase**: This is the final phase of cell division where the chromosomes are separated and move to opposite poles. There is no doubling of DNA in this phase.

3. **Conclusion**: The DNA content is doubled during the **interphase**, specifically during the S phase of interphase.

**Final Answer**: The DNA content is doubled during **interphase**.

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