The shape of RBCs of sickle cell anaemia patients change to elongated sickle like structure. Give reason.

Explanation

`Hb^(s)` belhaves as normal haemoglobin except under oxygen stress where erythroeytes lose their circular shape and become sickle-shaped. As a result, the cells cannot pass through narrow capillaries. Blood capillaries are clogged and thus affects blood supply to different organs.