Purified antibiotic penicillin of Penicillium notatum was obtained by

Options

A. A. Flemming
B. Howard Florey
C. Robert Hooke
D. Carolus Linnaeus

Answer

**Step-by-Step Solution:**

1. **Identify the Source of Penicillin**: Penicillin is an antibiotic derived from the fungus *Penicillium notatum*.

2. **Historical Context**: The discovery of penicillin was made by Alexander Fleming in 1928. He was conducting experiments with bacterial cultures, specifically with *Staphylococcus aureus*.

3. **Accidental Discovery**: Fleming noticed that in areas where the fungus *Penicillium notatum* was growing, the *Staphylococcus aureus* bacteria were being inhibited or killed. This led him to conclude that the fungus was producing a substance that could kill bacteria.

4. **Purification of Penicillin**: Although Fleming discovered penicillin, the process of purifying and extracting it for medical use was carried out by Howard Florey and Ernst Boris Chain. They developed methods to produce penicillin in large quantities, making it available for therapeutic use.

5. **Recognition and Awards**: In 1945, Fleming, Florey, and Chain were awarded the Nobel Prize in Physiology or Medicine for their contributions to the discovery and development of penicillin.

6. **Conclusion**: Therefore, while Alexander Fleming is credited with the discovery of penicillin, Howard Florey is recognized for obtaining the purified antibiotic form.

**Final Answer**: The purified antibiotic penicillin of *Penicillium notatum* was obtained by Howard Florey.

---