What is true about regulation of respiration -

Options

A. Respiratory rhythm centre lie on pons region.
B. The role of oxygen in the regulation of respiratory rhythm is quite insignificant.
C. Chemosensitive area of brain can recognise changes in `O_(2)`
D. Neural signal from pneumotaxic centre can not change the duration of inspiration.

Answer

### Step-by-Step Solution:

1. **Identify the Regulation of Respiration**: The regulation of respiration is primarily controlled by the respiratory centers located in the brain, specifically in the medulla oblongata and pons.

2. **Correct Location of the Respiratory Rhythm Center**: The respiratory rhythm center is located in the medulla oblongata, not in the pons. This is an important distinction as it clarifies where the primary control of breathing rhythm occurs.

3. **Role of Oxygen in Respiratory Rhythm**: The role of oxygen in regulating respiratory rhythm is relatively insignificant compared to carbon dioxide levels. The primary triggers for changes in respiration rate are the concentrations of carbon dioxide (CO2) and hydrogen ions (H+), rather than oxygen.

4. **Chemo-sensitive Area**: The chemo-sensitive area of the brain primarily responds to changes in carbon dioxide and hydrogen ion concentrations, rather than oxygen levels. This means that while oxygen levels are important for overall respiration, they do not directly influence the respiratory rhythm as much as CO2 and H+ do.

5. **Neural Signals from Pneumotaxic Center**: The pneumotaxic center does influence the duration of inspiration, but it is not the sole regulator of respiratory rhythm. The respiratory rhythm is continuously adjusted based on metabolic needs, which means that it is not fixed and can change dynamically.

6. **Conclusion**: Based on the above points, the only true statement regarding the regulation of respiration is that the role of oxygen in respiratory rhythm is quite insignificant, as the primary regulators are carbon dioxide and hydrogen ions.

### Final Answer:
The correct statement about the regulation of respiration is that the role of oxygen in respiratory rhythm is quite insignificant.

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