Which point is incorrect about Myasthenia gravis disease :-

Options

A. Neuromuscular junction is affected
B. Auto-immune disorder
C. Secretion from nerve terminal is reduced
D. Can lead to fatigue, weakining and paralysis of skeletal muscle

Answer

### Step-by-Step Solution:

1. **Understanding Myasthenia Gravis**: Myasthenia gravis is an autoimmune disease where the immune system produces antibodies that attack the body’s own muscle receptors, specifically at the neuromuscular junction.

2. **Mechanism of Action**: The antibodies block or destroy the acetylcholine receptors on the muscle cells. Acetylcholine is a neurotransmitter that is essential for muscle contraction. When the receptors are blocked, the muscle cells cannot receive adequate signals to contract.

3. **Symptoms of Myasthenia Gravis**: Due to the reduced number of functional receptors, patients experience muscle weakness, fatigue, and in severe cases, paralysis of skeletal muscles.

4. **Evaluating Statements**: The question requires identifying the incorrect statement about myasthenia gravis. The statements typically include:
- Neuromuscular junction is affected.
- It is an autoimmune disorder.
- Secretion from nerve terminals is reduced.
- It can lead to fatigue, weakness, and paralysis of skeletal muscles.

5. **Identifying the Incorrect Statement**:
- The first two statements are correct: the neuromuscular junction is indeed affected, and it is an autoimmune disorder.
- The last statement is also correct as myasthenia gravis leads to fatigue, weakness, and paralysis.
- The third statement, "Secretion from nerve terminals is reduced," is incorrect. The secretion of acetylcholine is not reduced; rather, the issue lies in the receptors being blocked.

6. **Conclusion**: The incorrect statement about myasthenia gravis is that "Secretion from nerve terminals is reduced."