Interphase is the time of active metabolic reactions both in the nucleus and cytoplasm.

Answer

### Step-by-Step Solution:

1. **Understanding Interphase**:
- Interphase is the phase of the cell cycle that occurs between successive mitotic divisions. It is not a resting phase, but rather a time of active metabolic processes.

2. **Phases of Interphase**:
- Interphase is divided into three sub-phases: G1 (Gap 1), S (Synthesis), and G2 (Gap 2). Each of these phases plays a crucial role in preparing the cell for division.

3. **Active Metabolic Reactions**:
- During interphase, the cell undergoes various metabolic activities. This includes:
- **Cell Growth**: The cell increases in size and synthesizes proteins and organelles.
- **DNA Replication**: In the S phase, the cell replicates its DNA, ensuring that each daughter cell will have an identical set of chromosomes.
- **Preparation for Mitosis**: In the G2 phase, the cell continues to grow and prepares for mitosis by synthesizing the necessary proteins and organelles.

4. **Nucleus and Cytoplasm Activity**:
- The metabolic reactions occur in both the nucleus (where DNA is replicated and processed) and the cytoplasm (where proteins and organelles are synthesized). This indicates that interphase is a time of significant activity in both compartments of the cell.

5. **Conclusion**:
- Therefore, the statement "Interphase is the time of active metabolic reactions both in the nucleus and cytoplasm" is true, as interphase is essential for cell growth, DNA replication, and preparation for cell division.