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What reaction is used for converting a p...

What reaction is used for converting a primary amide into a primary amine containing one carbon atom less than the parent amide ?

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To convert a primary amide into a primary amine containing one carbon atom less than the parent amide, we can use the Hofmann degradation reaction. Here’s a step-by-step breakdown of the reaction: ### Step 1: Identify the Reactants The primary amide can be represented as R-C(=O)-NH2, where R is an alkyl or aryl group. The reaction requires bromine (Br2) and a strong base, typically potassium hydroxide (KOH). ### Step 2: Reaction with Base When the primary amide is treated with KOH, the hydroxide ion (OH-) from KOH deprotonates the amide nitrogen. This forms an intermediate anion: \[ R-C(=O)-NH^- \] ...
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Hofmann rearrangement In the Hofmann rearrangement an unsubstitued amide is treated with sodium hydroxide and bromine to give a primary amine that has one carbon lesser than starting amide. Gneral reaction: If the migrating group is chiral then its configuration is retained. Electron releasing effects in the migrating group increase reactivity of Hofmann rearangement. Arrange the following amides according to their relative reactivity when reacted with Br_(2) in excess of strong base:

Hofmann rearrangement In the Hofmann rearrangement an unsubstitued amide is treated with sodium hydroxide and bromine to give a primary amine that has one carbon lesser than starting amide. Gneral reaction: If the migrating group is chiral then its configuration is retained. Electron releasing effects in the migrating group increase reactivity of Hofmann rearangement. Which of the following compound(s) cannot give Hoffman rearrangement:

ICSE-ORGANIC COMPOUNDS CONTAINING NITROGEN-EXERCISE (PART-II DESCRIPTIVE QUESTIONS- VERY SHORT ANSWER QUESTIONS )
  1. How would you convert propanenitrile to propanamine?

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  2. What reagent is used for converting a amide into an amine with the sam...

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  3. What reaction is used for converting a primary amide into a primary am...

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  4. Write the chemical reaction for the reduction of nitroethane by LiAIH4

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  5. What is ammonolysis?

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  6. Why do amines act as nucleophiles ?

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  7. Which out of isomeric amines has highest boiling point and why?

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  8. Why lower amines are soluble in water?

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  9. Why amines are less soluble in water as compared to alcohols?

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  10. Which type of amines are prepared by Gabriel phthalimide reaction?

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  11. Why aniline appears red in colour on standing in air for a long time?

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  12. Why is an alkylamine more basic than ammonia ?

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  13. Do as directed : (i) Arrange the following compounds in the increasi...

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  14. Of methylamine and aniline, which is a stronger base and why?

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  15. Cyclohexylamine is stronger base than aniline because

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  16. CH3 CONH2 is a weaker base than CH3 CH2 NH2.

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  17. How is the basic strength of aromatic amines affected by the presence ...

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  18. Identify A and B in the following sequence : CH3COOC2 H5 overset(NH...

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  19. Why is carbon-nitrogen bond length in aromatic amines shorter than in ...

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  20. How is phenylaminomethane obtained from phenylnitrile ?

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