The pKa of acetylsalicylic acid (aspirin...

The `pK_a` of acetylsalicylic acid (aspirin) is 3.5. The pH of gastric juice in the human stomach is about 2 to 3 and the pH in small intestine is about 8. Aspirin will be:

unionized in the small intestine and in the stomach

completely ionized in the small intestine and in the stomach

ionized in the stomach and almost unionized in the small intestine

ionized in the small intestine and almost unionized in the stomach

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