Which of the following pair is characterised by swollen lips, thick pigmented skin of hands and legs and irritability

Options

A. Thiamine- Beri-beri
B. Protein- Kwashiorkor
C. Nicotinamide- Pellagra
D. Iodine- Goitre

Explanation

To solve the question regarding which pair is characterized by swollen lips, thick pigmented skin of hands and legs, and irritability, we will analyze each option provided.

### Step-by-Step Solution:

1. **Identify the Symptoms**: The symptoms we need to focus on are swollen lips, thick pigmented skin of hands and legs, and irritability.

2. **Evaluate Option A - Thiamine (Vitamin B1)**:
- Thiamine deficiency is associated with Beriberi disease.
- Symptoms of Beriberi include muscle weakness and neurological issues, not swollen lips or thick pigmented skin.
- **Conclusion**: Option A is incorrect.

3. **Evaluate Option B - Protein Deficiency (Kwashiorkor)**:
- Kwashiorkor is a severe form of protein deficiency, particularly in children over 1 year of age.
- Symptoms include a pot-belly appearance, edema, and irritability, but not specifically swollen lips or thick pigmented skin.
- **Conclusion**: Option B is incorrect.

4. **Evaluate Option C - Nicotinamide (Vitamin B3)**:
- Nicotinamide deficiency leads to Pellagra.
- Pellagra is characterized by the "three D's": Dermatitis, Diarrhea, and Dementia.
- Specifically, Pellagra symptoms include swollen lips and thick pigmented skin, aligning with the symptoms given in the question.
- **Conclusion**: Option C is correct.

5. **Evaluate Option D - Iodine Deficiency**:
- Iodine deficiency causes Goiter, characterized by swelling of the thyroid gland.
- This condition does not relate to the symptoms mentioned in the question.
- **Conclusion**: Option D is incorrect.

### Final Answer:
The correct option is **C - Nicotinamide (Vitamin B3)**, which is associated with Pellagra, characterized by swollen lips, thick pigmented skin of hands and legs, and irritability.

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