Which of the following hormones can play a significant role in osteoporosis

Options

A. Estrogen and parathyroid hormone
B. Progesterone and aldosterone
C. Aldosterone and prolactin
D. Parathyroid hormone and prolactin

Explanation

Estrogen and parathyroid hormone can play significant role in osteoporosis . It is caused due to the deficiency of estrogen and excessive activity of parathormones . Estrogen helps to promote the activity of osteoblast (helps in the formation of bone cells ) and inhibits osteoclast (destruct the bones) . On the other hand , parathormone promotes the mobilisation of calcium from bones into blood hence causes demineralisation.
The other listed hormones also contribute to osteoporosis but their effects are insignificant or very less , e.g., low level of progesterone and aldosterone cause bone loss whereas raised level of prolactin have been linked with osteoporosis.