Which of the following is correct match of the disease with the associated chromosome

Options

A. Down Syndrome = 21st Chromosome
B. Sickel cell anaemia = X – Chromosome
C. Haemophilia = Y – Chromosome
D. Parkinson Disease = X & Y Chromosome

Answer

To solve the question regarding the correct match of the disease with the associated chromosome, we will analyze each option provided.

### Step-by-Step Solution:

1. **Identify the Diseases and Their Chromosomal Associations:**
- We have several diseases listed with their supposed chromosomal associations. We need to verify each one.

2. **Option 1: Down's Syndrome**
- Down's syndrome is known to be caused by trisomy of the 21st chromosome. This means that individuals with Down's syndrome have three copies of chromosome 21 instead of the usual two.
- **Conclusion:** This option is correct.

3. **Option 2: Sickle Cell Anemia**
- Sickle cell anemia is an autosomal recessive disorder, and it is associated with a mutation on chromosome 16, not the X chromosome.
- **Conclusion:** This option is incorrect.

4. **Option 3: Hemophilia**
- Hemophilia is a sex-linked disorder that is associated with the X chromosome. It is caused by a mutation in genes on the X chromosome, affecting blood clotting.
- **Conclusion:** This option is correct.

5. **Option 4: Parkinson's Disease**
- Parkinson's disease is a neurodegenerative disorder that is not specifically linked to the X or Y chromosomes. It is primarily associated with the loss of dopamine-producing neurons in the brain.
- **Conclusion:** This option is incorrect.

6. **Final Evaluation:**
- The only correct match from the options provided is Down's syndrome with chromosome 21. Hemophilia also correctly matches with the X chromosome, but since the question asks for the correct match, we will focus on the first option as the primary answer.

### Final Answer:
The correct match of the disease with the associated chromosome is **Option 1: Down's Syndrome with Chromosome 21**.

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