Antibiotic inhibiting interaction between tRNA and mRNA during protein synthesis in bacteria

Options

A. Erythromycin
B. Neomycin
C. Streptomycin
D. Tetracycline

Answer

**Step-by-Step Solution:**

1. **Understanding the Question**: The question asks for an antibiotic that inhibits the interaction between tRNA and mRNA during protein synthesis in bacteria. This means we need to identify an antibiotic that affects the translation process by interfering with the binding of tRNA to mRNA.

2. **Identifying Relevant Antibiotics**: Several antibiotics are known to affect protein synthesis in bacteria, including erythromycin, neomycin, streptomycin, and tetracycline. We need to focus on their mechanisms of action.

3. **Mechanism of Action of Neomycin**: Neomycin is classified as an aminoglycoside antibiotic. It specifically binds to the 30S ribosomal subunit of bacteria. This binding is crucial because the 30S subunit is involved in the initiation and elongation phases of protein synthesis.

4. **Effect of Neomycin on Protein Synthesis**: When neomycin binds to the 30S ribosomal subunit, it interferes with the proper binding of mRNA and tRNA. This disruption leads to the production of non-functional or toxic peptides, as the translation process is impaired.

5. **Conclusion**: Based on the mechanism of action described, the antibiotic that inhibits the interaction between tRNA and mRNA during protein synthesis in bacteria is **neomycin**.

---