The totality of metabolism in humans must include both anabolism and catabolism.

Answer

**Step-by-Step Text Solution:**

1. **Understanding Metabolism**: Metabolism refers to the total chemical processes that occur within a living organism to maintain life. It encompasses all the biochemical reactions that take place in the body.

2. **Components of Metabolism**: Metabolism is broadly divided into two categories:
- **Anabolism**: This is the constructive phase of metabolism where simple molecules are built up into more complex molecules. This process requires energy and is essential for growth, repair, and maintenance of cells. For example, the synthesis of proteins from amino acids is an anabolic process.
- **Catabolism**: This is the destructive phase of metabolism where complex molecules are broken down into simpler ones, releasing energy in the process. This energy is often used for various cellular functions. An example of catabolism is the breakdown of glucose during cellular respiration.

3. **The Relationship Between Anabolism and Catabolism**: Both anabolic and catabolic processes are interconnected. The energy released from catabolic reactions is used to drive anabolic reactions. Therefore, both processes are essential for maintaining the metabolic balance in the body.

4. **Conclusion**: Given that metabolism includes both the synthesis of biomolecules (anabolism) and the breakdown of substrates to generate energy (catabolism), the statement that the totality of metabolism in humans must include both anabolism and catabolism is indeed true.

**Final Answer**: The statement is true because metabolism encompasses both anabolic and catabolic processes.

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