What happens to the action site of the enzyme in non-competitive inhibition?

Explanation

### Step-by-Step Solution:

1. **Understanding Non-Competitive Inhibition**: Non-competitive inhibition occurs when an inhibitor binds to an enzyme at a site other than the active site. This binding does not prevent the substrate from binding to the active site but affects the enzyme's function.

2. **Active Site and Substrate Binding**: The active site of an enzyme is the region where the substrate binds. In non-competitive inhibition, the inhibitor binds to a different site on the enzyme, which alters the enzyme's shape.

3. **Effect of Inhibitor Binding**: When the non-competitive inhibitor binds to the enzyme, it causes a conformational change (shape change) in the enzyme. This change affects the enzyme's ability to catalyze the reaction, even if the substrate is bound to the active site.

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