During cell division, chromosome attaches with spindles at:

Options

A. kinetochore
B. centromere
C. centriole
D. secopdary constriction

Answer

To answer the question "During cell division, chromosome attaches with spindles at:", we need to analyze the options provided and understand the process of cell division, particularly during the metaphase stage.

### Step-by-Step Solution:

1. **Understanding Cell Division**:
- Cell division occurs in two main phases: mitosis and cytokinesis. Mitosis is further divided into several stages: prophase, metaphase, anaphase, and telophase.

2. **Identifying the Relevant Stage**:
- The question specifically refers to the attachment of chromosomes to spindle fibers, which primarily occurs during the metaphase stage of mitosis.

3. **Analyzing the Options**:
- The options given are:
- A) Kinetochore
- B) Centromere
- C) Centriole
- D) Secondary constriction

4. **Defining Each Term**:
- **Kinetochore**: A protein structure on the chromosome where spindle fibers attach during cell division.
- **Centromere**: The region of a chromosome where the two sister chromatids are joined. The kinetochore forms at the centromere.
- **Centriole**: A cylindrical structure involved in the formation of spindle fibers but does not directly attach to chromosomes.
- **Secondary constriction**: A region on some chromosomes that may not be directly involved in spindle attachment.

5. **Correct Answer**:
- The correct answer is **Kinetochore**. This is where the spindle fibers attach to the chromosomes during metaphase.

6. **Conclusion**:
- Therefore, during cell division, chromosomes attach to spindles at the kinetochore.