Bulk of histone proteins are synthesized in

Options

A. `G_(1)` phase
B. `G_(2)` phase
C. S phase
D. `G_(0)` phase

Answer

To answer the question "Bulk of histone proteins are synthesized in," we need to analyze the cell cycle phases and identify where histone protein synthesis predominantly occurs.

### Step-by-Step Solution:

1. **Understanding the Cell Cycle**: The cell cycle consists of two main phases: Interphase and M phase (mitosis). Interphase is further divided into three phases: G1 phase, S phase, and G2 phase.

2. **Identifying the Phases**:
- **G1 Phase (Gap 1)**: This is the phase before DNA synthesis begins. The cell grows and prepares for DNA replication.
- **S Phase (Synthesis)**: This is the phase where DNA replication occurs. The cell synthesizes a complete copy of the DNA in its nucleus, which includes the synthesis of histone proteins that package the DNA.
- **G2 Phase (Gap 2)**: This phase occurs after DNA synthesis. The cell continues to grow and prepares for mitosis.

3. **Focusing on Histone Protein Synthesis**: Histone proteins are essential for DNA packaging and are crucial during the replication of DNA. Since the S phase is specifically designated for DNA synthesis, it is also the phase where the bulk of histone proteins are synthesized to package the newly replicated DNA.

4. **Conclusion**: Based on the understanding of the cell cycle and the role of histone proteins, we conclude that the bulk of histone proteins are synthesized during the S phase of the cell cycle.

### Final Answer:
The bulk of histone proteins are synthesized in the **S phase**.

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