In which stage of the cell cycle are histone proteins synthesised in a eukaryotic cells ?

Options

A. During telophase
B. During S phase
C. During `G_(2)` stage of prophase
D. During entire prophase

Answer

To determine the stage of the cell cycle in which histone proteins are synthesized in eukaryotic cells, we can follow these steps:

### Step-by-Step Solution:

1. **Understanding the Cell Cycle**: The cell cycle consists of several phases: G1 (Gap 1), S (Synthesis), G2 (Gap 2), and M (Mitosis). Each phase has specific functions and activities.

2. **Identifying Protein Synthesis Phases**: Protein synthesis occurs primarily during the G1 and G2 phases. During the G1 phase, some proteins are synthesized, but not all types, including histones.

3. **Focus on Histone Protein Synthesis**: Histone proteins are essential for DNA packaging and are particularly important during the DNA replication process.

4. **Locating the S Phase**: The S phase is when DNA replication occurs, and histone proteins are needed to package the newly synthesized DNA. However, the actual synthesis of histone proteins begins before this phase.

5. **G2 Phase Role**: The G2 phase is crucial because it is when the bulk of histone proteins are synthesized in preparation for mitosis. This phase acts as a checkpoint to ensure that the cell is ready to divide.

6. **Conclusion**: Therefore, the stage of the cell cycle where histone proteins are synthesized predominantly is during the **G2 phase**.

### Final Answer:
Histone proteins are synthesized primarily during the **G2 phase** of the cell cycle in eukaryotic cells.

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