Colchicine, a mitotic poison, arrests the cell division in

Options

A. `G_(1)` phase
B. `G_(2)` phase
C. Anaphase
D. Metaphase

Answer

To solve the question regarding the effect of colchicine on cell division, we can follow these steps:

### Step-by-Step Solution:

1. **Understanding Colchicine**:
- Colchicine is known as a mitotic poison. It interferes with the normal process of cell division.

2. **Mechanism of Action**:
- Colchicine disrupts the formation of the mitotic spindle, which is crucial for separating chromosomes during cell division. It does this by binding to tubulin, a protein that is a key component of microtubules.

3. **Identifying the Cell Cycle Phases**:
- The cell cycle consists of several phases: G1, S, G2, and M (which includes metaphase and anaphase).
- The M phase is where mitosis occurs, and it is further divided into several stages, including prophase, metaphase, anaphase, and telophase.

4. **Effect of Colchicine**:
- Since colchicine prevents the proper assembly of the mitotic spindle, it specifically arrests the cell division during metaphase. This is the stage where chromosomes align at the cell's equatorial plane and are prepared for separation.

5. **Conclusion**:
- Therefore, the correct answer to the question is that colchicine arrests cell division in the **metaphase**.

### Final Answer:
Colchicine, a mitotic poison, arrests cell division in **metaphase**.

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