Which is not an important intermediate of PPP (HMS) ?

Options

A. `NADPH_(2)`,
B. Erythrose 4phosphate
C. Ribulose
D. Aromatic compounds

Answer

To determine which option is not an important intermediate of the Pentose Phosphate Pathway (PPP), also known as the Hexose Monophosphate Shunt (HMS), we will analyze each of the given options:

1. **NADPH**: This is a crucial product of the PPP. It is used in various biosynthetic reactions and is essential for maintaining the cellular redox state. Therefore, NADPH is an important intermediate in the PPP.

2. **Erythrose 4-phosphate**: This is another important intermediate in the PPP. It plays a role in the synthesis of aromatic amino acids and is involved in the pathway. Thus, erythrose 4-phosphate is also an important intermediate.

3. **Ribulose**: Ribulose, specifically ribulose-5-phosphate, is a key intermediate in the PPP. It is involved in the conversion of ribulose-5-phosphate to ribose-5-phosphate, which is important for nucleotide synthesis. Hence, ribulose is an important intermediate.

4. **Aromatic compounds**: Aromatic compounds are not intermediates in the Pentose Phosphate Pathway. They are products of other metabolic pathways, but they do not play a direct role in the PPP.

Based on this analysis, the answer to the question "Which is not an important intermediate of PPP (HMS)?" is **aromatic compounds**.

### Summary of Steps:
1. Identify the options given in the question.
2. Analyze each option to determine if it is an important intermediate in the PPP.
3. Conclude that aromatic compounds are not an important intermediate in the PPP.