In TCA cycle, the conversion of succinyl CoA to succinic acid requires

Options

A. Acetyl CoA + GTP + iP
B. Acetyl CoA + GDP + iP
C. CoA + GTP + iP
D. GDP + iP

Answer

To answer the question regarding the conversion of succinyl CoA to succinic acid in the TCA cycle, we can follow these steps:

### Step-by-Step Solution:

1. **Understanding the TCA Cycle**:
- The TCA cycle, also known as the tricarboxylic acid cycle or citric acid cycle, occurs in the mitochondrial matrix. It plays a crucial role in cellular respiration by oxidizing acetyl CoA to produce energy.

2. **Identifying the Reaction**:
- The specific reaction we are looking at is the conversion of succinyl CoA to succinic acid. This is an important step in the TCA cycle.

3. **Components Required for the Reaction**:
- To convert succinyl CoA to succinic acid, we need to release the CoA group from succinyl CoA. This process requires specific substrates.
- The reaction requires:
- GDP (Guanosine Diphosphate)
- Inorganic phosphate (Pi)
- The release of CoA

4. **Understanding the Role of GDP and Inorganic Phosphate**:
- GDP is involved in the phosphorylation process, where it gets converted to GTP (Guanosine Triphosphate) during this reaction.
- Inorganic phosphate is required to facilitate the conversion and to help in the formation of GTP from GDP.

5. **Final Reaction**:
- The overall reaction can be summarized as:
- Succinyl CoA + GDP + Pi → Succinic Acid + CoA + GTP

### Conclusion:
The conversion of succinyl CoA to succinic acid in the TCA cycle requires GDP and inorganic phosphate.