Assertion :- Glucose 6-phosphate dehydrogenase deficiency impairs PPP (HMS).
Reason :- It is an X-linked recessive disorder.

Options

A. If both Assertion and Reason are true and the Reason is the correct explanation of the Assertion.
B. If both Assertion and Reason are true, but the Reason is not the correct explanation of the Assertion.
C. If Assertion is true, but Reason is flase.
D. If both Assertion and Reason are false.

Answer

To analyze the given assertion and reason, we will break down the information step by step.

### Step 1: Understand the Assertion
The assertion states that "Glucose 6-phosphate dehydrogenase deficiency impairs PPP (HMS)."
- Glucose 6-phosphate dehydrogenase (G6PD) is an enzyme that plays a crucial role in the pentose phosphate pathway (PPP), also known as the hexose monophosphate shunt (HMS).
- The PPP is important for producing NADPH and ribose-5-phosphate, which are essential for various biosynthetic reactions and cellular functions.

### Step 2: Analyze the Role of G6PD
- G6PD catalyzes the first step of the PPP, converting glucose 6-phosphate into 6-phosphogluconolactone.
- If there is a deficiency of G6PD, this conversion cannot occur, leading to impaired functioning of the pentose phosphate pathway.

### Step 3: Conclusion on the Assertion
- Since G6PD is essential for the initiation of the PPP, a deficiency in this enzyme indeed impairs the pathway.
- Therefore, the assertion is **true**.

### Step 4: Understand the Reason
The reason states that "It is an X-linked recessive disorder."
- G6PD deficiency is inherited in an X-linked recessive manner, meaning that the gene responsible for this condition is located on the X chromosome.
- This type of inheritance pattern explains why males (who have one X chromosome) are more likely to express the disorder than females (who have two X chromosomes).

### Step 5: Conclusion on the Reason
- The reason provided is also **true** as G6PD deficiency is indeed an X-linked recessive disorder.

### Step 6: Evaluate the Relationship Between Assertion and Reason
- While both the assertion and reason are true, the reason does not explain why G6PD deficiency impairs the PPP. It only describes the inheritance pattern of the deficiency.
- The assertion is about the functional impairment of the PPP due to enzyme deficiency, while the reason discusses the genetic inheritance of the deficiency.

### Final Conclusion
- Both the assertion and the reason are true, but the reason is **not the correct explanation** for the assertion.

### Summary Answer
- **Assertion**: True
- **Reason**: True
- **Explanation**: The reason is not the correct explanation of the assertion.

---