The cells in the wall of intestine are stimulated to produce scretin by

Options

A. Cholycystokinin
B. Bile juice
C. Acid in chyme
D. Gastrin

Answer

To answer the question "The cells in the wall of the intestine are stimulated to produce secretin by," we can follow these steps:

### Step-by-Step Solution:

1. **Understanding Secretin**: Secretin is a hormone produced by the cells in the wall of the duodenum, which is the first part of the small intestine.

2. **Stimulus for Secretin Production**: The production of secretin is primarily stimulated by the presence of acidic chyme in the duodenum. When partially digested food (chyme) from the stomach enters the duodenum, it is often acidic due to the presence of hydrochloric acid.

3. **Role of Hydrochloric Acid**: The hydrochloric acid in the chyme triggers the cells in the intestinal wall to release secretin into the bloodstream. This is a critical response to help neutralize the acidity of the chyme.

4. **Function of Secretin**: Once secretin is released, it acts on the pancreas and liver, stimulating them to secrete bicarbonate-rich pancreatic juice and bile, respectively. This helps to neutralize the acid and provides an optimal pH for the enzymes that digest food.

5. **Conclusion**: Therefore, the cells in the wall of the intestine are stimulated to produce secretin by the presence of acid in the chyme.

### Final Answer:
The cells in the wall of the intestine are stimulated to produce secretin by the acid in the chyme.

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