Assertion: In humans, the duct of Wirsung from pancreas combines with bile duct before opening into duodenum.
Reason: Blockage in the duct of Wirsung will hamper the endocrine function of pancreas

Answer

**Step-by-Step Solution:**

1. **Understanding the Assertion:**
- The assertion states that in humans, the duct of Wirsung (the main pancreatic duct) combines with the bile duct before opening into the duodenum.
- The duct of Wirsung is indeed the main pancreatic duct that carries digestive enzymes from the pancreas to the duodenum.

2. **Analyzing the Duct Connection:**
- The duct of Wirsung does combine with the bile duct, which carries bile from the liver and gallbladder.
- Together, these ducts form a common duct known as the hepatopancreatic duct (also called the ampulla of Vater) before they empty into the duodenum.

3. **Conclusion on the Assertion:**
- Since the duct of Wirsung does combine with the bile duct before opening into the duodenum, the assertion is **true**.

4. **Understanding the Reason:**
- The reason states that a blockage in the duct of Wirsung will hamper the endocrine function of the pancreas.
- The pancreas has both endocrine (hormone secretion) and exocrine (digestive enzyme secretion) functions.

5. **Analyzing the Endocrine Function:**
- The endocrine function of the pancreas involves the secretion of hormones like insulin and glucagon directly into the bloodstream.
- This function is **ductless**, meaning it does not rely on ducts for hormone release.

6. **Conclusion on the Reason:**
- Since the endocrine function does not depend on the duct of Wirsung, a blockage in this duct would **not** affect the endocrine function of the pancreas. Therefore, the reason is **false**.

7. **Final Evaluation:**
- The assertion is true, and the reason is false. Thus, the correct answer is that the assertion is correct, but the reason is incorrect.