Which of the following sequence is correct?
(i) An increase in body fluid volume `rarr` switch off the osmoreceptors `rarr` suppresses the ADH Release
(ii) ADH `rarr` Constricting effect on blood vessel `rarr` B.P. high `rarr` Glomerular blood flow more `rarr` GFR more
(iii) Angiotensinogen `rarr` Angiotensin I `rarr` Angiotensin II `rarr` Adrenal cortex `rarr` Aldosterone
(iv) Angiotensin `rarr` ADH `rarr` GFR more `rarr` Aldosterone `rarr` B.P. high
(a) i, ii and iii
(b) i, ii and iv
(c) ii, iii and iv
(d) iii, iv and ii

Options

A. i, ii and iii
B. i, ii and iv
C. ii, iii and iv
D. iii, iv and ii

Answer

To determine the correct sequence of events related to the regulation of body fluid volume and the hormones involved, we will analyze each statement provided in the question.

### Step-by-Step Solution:

1. **Analyzing Statement (i)**:
- "An increase in body fluid volume → switch off the osmoreceptors → suppresses the ADH Release"
- When body fluid volume increases, osmoreceptors detect this change and are switched off. This leads to a suppression of the release of Antidiuretic Hormone (ADH) from the neurohypophysis.
- **Conclusion**: This statement is correct.

2. **Analyzing Statement (ii)**:
- "ADH → Constricting effect on blood vessel → B.P. high → Glomerular blood flow more → GFR more"
- ADH causes vasoconstriction, which increases blood pressure (B.P.). An increase in blood pressure enhances glomerular blood flow, which in turn increases the Glomerular Filtration Rate (GFR).
- **Conclusion**: This statement is also correct.

3. **Analyzing Statement (iii)**:
- "Angiotensinogen → Angiotensin I → Angiotensin II → Adrenal cortex → Aldosterone"
- Angiotensinogen is converted to Angiotensin I, which is then converted to Angiotensin II. Angiotensin II acts on the adrenal cortex to stimulate the release of aldosterone.
- **Conclusion**: This statement is correct as well.

4. **Analyzing Statement (iv)**:
- "Angiotensin → ADH → GFR more → Aldosterone → B.P. high"
- This sequence is misleading. While Angiotensin II can stimulate the release of ADH and aldosterone, the sequence implies that an increase in GFR directly leads to aldosterone release, which is not accurate. Aldosterone release is primarily stimulated by Angiotensin II and not directly by GFR.
- **Conclusion**: This statement is not correct.

### Final Conclusion:
The correct sequences are (i), (ii), and (iii). Therefore, the correct answer is:
**(a) i, ii and iii**

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