During mechanism of action of insulin, protein kinase C is activated by
(a) `PIP_2`
(b) `IP_3`
(c) `DG `
(d) `Ca^(2+)`

Options

A. `PIP_2`
B. `IP_3`
C. `DG `
D. `Ca^(2+)`

Answer

To determine which component activates protein kinase C (PKC) during the mechanism of action of insulin, we can follow these steps:

### Step-by-Step Solution:

1. **Understanding Insulin's Mechanism of Action**:
- Insulin is a hormone that plays a crucial role in regulating glucose levels in the blood. Its action involves a series of biochemical pathways.

2. **Identifying Protein Kinase C (PKC)**:
- PKC is an important enzyme that is involved in various signal transduction pathways. It is activated by specific molecules in response to hormonal signals.

3. **Components Involved in PKC Activation**:
- The options given are:
- (a) PIP2 (Phosphatidylinositol 4,5-bisphosphate)
- (b) IP3 (Inositol trisphosphate)
- (c) DG (Diacylglycerol)
- (d) Ca²⁺ (Calcium ions)

4. **Role of Diacylglycerol (DAG)**:
- Among these components, diacylglycerol (DAG) is known to be a key activator of PKC. When insulin binds to its receptor, it triggers a cascade that leads to the production of DAG.

5. **Conclusion**:
- Based on the mechanism of action of insulin and the role of DAG in activating PKC, the correct answer is (c) DG (Diacylglycerol).

### Final Answer:
(c) DG