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Which of the following are correct diffe...

Which of the following are correct differences between foetal haemoglobin (Hb-F) and adult haemoglobin (Hb-A) ?
(a) Hb-F has higher affinity for oxygen as compared to Hb-A
(b) The curve of Hb-F occurs towards the left of Hb-A
(c) Hb-F binds with BPG more strongly as compared to Hb-A
(d) `P_(50)` valve of Hb-F is less than `P_(50)` valve Hb-A

A

a,b,c,d

B

a,b,d

C

a,b,c

D

b,c,d

Text Solution

AI Generated Solution

The correct Answer is:
To determine the correct differences between fetal hemoglobin (Hb-F) and adult hemoglobin (Hb-A), let's analyze each option provided in the question step by step. ### Step-by-Step Solution: 1. **Understanding Hb-F and Hb-A**: - Fetal hemoglobin (Hb-F) is the type of hemoglobin found in the fetus, while adult hemoglobin (Hb-A) is the type found in adults. They have different properties, especially regarding their affinity for oxygen and their interaction with 2,3-BPG (2,3-bisphosphoglycerate). 2. **Analyzing Option (a)**: - **Statement**: Hb-F has higher affinity for oxygen as compared to Hb-A. - **Explanation**: This statement is true. Hb-F indeed has a higher affinity for oxygen than Hb-A, which allows the fetus to extract oxygen from maternal blood effectively. 3. **Analyzing Option (b)**: - **Statement**: The curve of Hb-F occurs towards the left of Hb-A. - **Explanation**: This statement is also true. The oxygen saturation curve for Hb-F is shifted to the left compared to that of Hb-A, indicating a higher affinity for oxygen. 4. **Analyzing Option (c)**: - **Statement**: Hb-F binds with BPG more strongly as compared to Hb-A. - **Explanation**: This statement is false. Hb-F binds to 2,3-BPG less tightly than Hb-A. This lower binding affinity contributes to its higher oxygen affinity. 5. **Analyzing Option (d)**: - **Statement**: P50 value of Hb-F is less than P50 value of Hb-A. - **Explanation**: This statement is true. The P50 value for Hb-F (approximately 19 mm Hg) is indeed less than that for Hb-A (approximately 27 mm Hg), indicating that Hb-F requires a lower partial pressure of oxygen to achieve 50% saturation. ### Conclusion: Based on the analysis: - **Correct Statements**: (a), (b), and (d). - **Incorrect Statement**: (c). Thus, the correct differences between fetal hemoglobin and adult hemoglobin are options (a), (b), and (d). ### Final Answer: The correct differences are (a), (b), and (d). ---
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