Which of the following statements is/are correct ?

Options

A. Hepatitis B virus (HBV) can be transmitted through blood transfusion, sesual contact, tears, intravenous drug abuse, tatooing, ear and nose pierceing, sharing of razors, etc.
B. Hepatitis B virus vaccine is the second generation vaccine produced from transgenic yeast by recombinant DNA technology.
C. Hepatitis B virus vaccine is the first commercially available human vaccine produced by genetic engineering.
D. All of these.

Answer

To determine which statements regarding Hepatitis B virus (HBV) and its vaccine are correct, we will analyze each statement one by one.

### Step-by-Step Solution:

1. **Analyze Statement A**:
- Statement A claims that Hepatitis B virus can be transmitted through various means including blood transfusion, sexual contact, tears, intravenous drug abuse, tattooing, ear and nose piercing, and sharing of razors.
- **Evaluation**: This statement is correct. Hepatitis B can indeed be transmitted through these routes, particularly through blood and sexual contact.

2. **Analyze Statement B**:
- Statement B states that the Hepatitis B virus vaccine is a second-generation vaccine produced from transgenic yeast by recombinant DNA technology.
- **Evaluation**: This statement is also correct. The Hepatitis B vaccine is classified as a second-generation vaccine and is produced using recombinant DNA technology involving transgenic yeast.

3. **Analyze Statement C**:
- Statement C asserts that the Hepatitis B virus vaccine is the first commercially available human vaccine produced by genetic engineering.
- **Evaluation**: This statement is correct as well. The Hepatitis B vaccine is indeed recognized as the first commercially available human vaccine that was developed using genetic engineering techniques.

4. **Conclusion**:
- Since all three statements (A, B, and C) are correct, the correct answer is option D, which states that all of these statements are correct.

### Final Answer:
**Option D: All of these statements are correct.**

---