Acetophenone can be obtained by the reaction of `PhMgBr` and.

Options

A. Ethane nitrile
B. Ethanamide
C. Ethanoyl chloride
D. Methanamide

Explanation

To determine which compound can react with phenyl magnesium bromide (PhMgBr) to yield acetophenone, we will analyze the possible options step by step.

### Step 1: Understanding the Reaction
Phenyl magnesium bromide is a Grignard reagent, which is a strong nucleophile. It can react with carbonyl compounds to form alcohols after hydrolysis. In this case, we want to obtain acetophenone, which has the structure:

\[ \text{Acetophenone: } \text{C}_6\text{H}_5\text{C(O)CH}_3 \]

### Step 2: Analyzing the Options
We need to identify which compounds can react with PhMgBr to yield acetophenone.

#### Option A: Ethanenitrile (Acetonitrile)
1. **Reaction with PhMgBr**:
- Ethanenitrile (CH₃C≡N) can react with PhMgBr.
- The reaction will involve the nucleophilic attack of PhMgBr on the carbon of the nitrile group, leading to the formation of an intermediate.

2. **Hydrolysis**:
- Upon hydrolysis, this intermediate will yield acetophenone.

#### Option B: Ethanoamide (Acetamide)
1. **Reaction with PhMgBr**:
- Ethanoamide (CH₃C(O)NH₂) can also react with PhMgBr.
- The nucleophilic attack will occur at the carbonyl carbon of the amide.

2. **Hydrolysis**:
- Hydrolysis of the resulting intermediate will again yield acetophenone.

### Step 3: Evaluating Other Options
#### Option C: Ethanoic Chloride (Acetyl Chloride)
1. **Reaction with PhMgBr**:
- Ethanoic chloride (CH₃C(O)Cl) will react with two moles of PhMgBr.

2. **Outcome**:
- This reaction will yield a tertiary alcohol, not acetophenone.

#### Option D: Methanamide (Formamide)
1. **Reaction with PhMgBr**:
- Methanamide (HCONH₂) will react with PhMgBr.

2. **Outcome**:
- This reaction will yield benzaldehyde (C₆H₅CHO), not acetophenone.

### Conclusion
From the analysis, we find that both ethane nitrile and ethanoamide can react with phenyl magnesium bromide to produce acetophenone. Therefore, the correct answers are:

**Answer: Ethanenitrile and Ethanoamide.**