The term anomer of glucose refers to:

Options

A. Isomers of glucose that differ in configuration at carbons one and four `(C-1 and C-4)`.
B. A mixture of `D-`glucose and `L-`glucose.
C. Enantiomers of glucose.
D. Isomers of glucose that differ in configuration at carbon one `(C-1)`

Answer

To answer the question "The term anomer of glucose refers to:", we need to understand the concept of anomers in carbohydrate chemistry, particularly in relation to glucose.

### Step-by-Step Solution:

1. **Definition of Anomer**: Anomers are a specific type of stereoisomer found in carbohydrates. They differ in configuration at the anomeric carbon, which is the carbon that was the carbonyl carbon (C=O) in the open-chain form of the sugar.

2. **Identifying the Anomeric Carbon**: In glucose, when it cyclizes to form a ring structure (either pyranose or furanose), the carbon that becomes the anomeric carbon is carbon 1 (C1). This carbon can have two different configurations based on the orientation of the hydroxyl group (OH) attached to it.

3. **Alpha and Beta Forms**:
- **Alpha (α) Anomer**: If the hydroxyl group on the anomeric carbon (C1) is oriented downward (trans to the CH2OH group at C5), it is referred to as the alpha anomer (α-D-glucopyranose).
- **Beta (β) Anomer**: If the hydroxyl group on the anomeric carbon (C1) is oriented upward (cis to the CH2OH group at C5), it is referred to as the beta anomer (β-D-glucopyranose).

4. **Conclusion**: Therefore, the term "anomer of glucose" specifically refers to isomers of glucose that differ in configuration at the anomeric carbon (C1).

5. **Correct Option**: Based on this understanding, the correct answer to the question is that anomers of glucose are isomers that differ in configuration at carbon 1.

### Final Answer:
The term anomer of glucose refers to isomers of glucose that differ in configuration at carbon 1.