Under which condition the oxygen dissociation curve will move towards the right ?

Options

A. Low `pO_(2)`
B. High `CO_(2)`
C. High `H^(+)` concentration and higher temperature
D. All of these

Answer

To determine the conditions under which the oxygen dissociation curve (ODC) shifts to the right, we need to analyze various physiological factors that influence the affinity of hemoglobin for oxygen. A rightward shift indicates a decreased affinity of hemoglobin for oxygen, facilitating oxygen release to tissues.

### Step-by-Step Solution:

1. **Understanding the Oxygen Dissociation Curve (ODC)**:
- The ODC illustrates the relationship between the partial pressure of oxygen (pO2) and the saturation of hemoglobin with oxygen (oxyhemoglobin).
- A rightward shift in the curve indicates that at a given pO2, hemoglobin is less saturated with oxygen, meaning it releases oxygen more readily.

2. **Identifying Conditions That Cause a Right Shift**:
- Several physiological conditions can lead to a rightward shift in the ODC:
- **Increased Temperature**: Higher body temperatures reduce hemoglobin's affinity for oxygen, promoting oxygen release.
- **Increased 2,3-Diphosphoglycerate (2,3-DPG)**: This metabolite binds to hemoglobin and decreases its affinity for oxygen, facilitating oxygen unloading.
- **Increased Hydrogen Ion Concentration (Low pH)**: An increase in hydrogen ions (H+) indicates a more acidic environment, which also reduces hemoglobin's affinity for oxygen.
- **Increased Carbon Dioxide (CO2)**: Higher levels of CO2 in the blood lead to an increase in H+ ions (due to the formation of carbonic acid), further promoting the right shift.

3. **Conclusion**:
- The conditions that cause the oxygen dissociation curve to shift to the right include:
- Increased temperature
- Increased levels of 2,3-DPG
- Increased hydrogen ion concentration (low pH)
- Increased carbon dioxide levels
- Therefore, the correct answer is that all of these conditions lead to a rightward shift of the ODC.