Which of the following stimulates the gluconeogenesis ?

Options

A. Calcitonin
B. Cortisol
C. Aldosterone
D. Thymosin

Answer

To determine which hormone stimulates gluconeogenesis, we can follow these steps:

### Step 1: Understand the term "gluconeogenesis"
Gluconeogenesis is the metabolic process through which glucose is synthesized from non-carbohydrate precursors. This process is crucial for maintaining blood glucose levels, especially during fasting or intense exercise.

### Step 2: Analyze the options provided
The options given are:
1. Calcitonin
2. Cortisol
3. Aldosterone
4. Thymosyn

### Step 3: Evaluate each hormone's function
- **Calcitonin**: This hormone is secreted by the thyroid gland and primarily regulates calcium levels in the blood. It does not play a role in glucose metabolism, making it an incorrect option.

- **Cortisol**: This is a glucocorticoid hormone secreted by the adrenal cortex. Cortisol is known to stimulate gluconeogenesis, especially during stress or low blood sugar conditions. This makes it a strong candidate for the correct answer.

- **Aldosterone**: This hormone is a mineralocorticoid secreted by the zona glomerulosa of the adrenal cortex. Its primary function is to regulate sodium and potassium levels, not glucose levels, so it is also incorrect.

- **Thymosyn**: This hormone is secreted by the thymus gland and is involved in the immune response. It does not influence glucose metabolism, making it incorrect as well.

### Step 4: Conclusion
After evaluating all the options, the hormone that stimulates gluconeogenesis is **Cortisol**.

### Final Answer:
**Cortisol stimulates gluconeogenesis.**

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