Which of the following pituitary hormones is known to have diabetogenic effect ?

Options

A. TSH
B. LH
C. GH
D. PRL

Answer

To determine which pituitary hormone is known to have a diabetogenic effect, we will analyze the functions of various hormones secreted by the pituitary gland and identify the one that increases blood glucose levels.

### Step-by-Step Solution:

1. **Understand the Concept of Diabetogenic Effect**:
- The term "diabetogenic effect" refers to the ability of a substance to increase blood glucose levels, potentially leading to diabetes.

2. **Identify the Pituitary Gland**:
- The pituitary gland is often referred to as the "master gland" because it regulates various endocrine functions by releasing hormones that act on other glands.

3. **Differentiate Between Pituitary Hormones**:
- The pituitary gland has two lobes: the anterior lobe and the posterior lobe.
- The anterior lobe secretes several hormones, including:
- Thyroid Stimulating Hormone (TSH)
- Luteinizing Hormone (LH)
- Follicle Stimulating Hormone (FSH)
- Growth Hormone (GH)
- Prolactin (PRL)
- Adrenocorticotropic Hormone (ACTH)
- The posterior lobe secretes:
- Oxytocin
- Vasopressin (Antidiuretic Hormone)

4. **Analyze Each Hormone's Function**:
- **Thyroid Stimulating Hormone (TSH)**: Stimulates the thyroid gland, regulating metabolism but not directly affecting blood glucose.
- **Luteinizing Hormone (LH)**: Regulates gonadal function, not related to glucose metabolism.
- **Follicle Stimulating Hormone (FSH)**: Also involved in reproductive processes, not glucose regulation.
- **Growth Hormone (GH)**: Increases cell activity and energy requirements, leading to increased glucose levels in the blood.
- **Prolactin (PRL)**: Primarily involved in lactation and does not affect blood glucose levels.
- **Adrenocorticotropic Hormone (ACTH)**: Stimulates cortisol release from the adrenal glands, which can influence glucose metabolism but is not directly a pituitary hormone with a known diabetogenic effect.

5. **Identify the Correct Answer**:
- Among the hormones listed, **Growth Hormone (GH)** is the one known to have a diabetogenic effect because it increases blood glucose levels by promoting gluconeogenesis and reducing glucose uptake in tissues.

### Conclusion:
The pituitary hormone known to have a diabetogenic effect is **Growth Hormone (GH)**.

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