Gynecomastia condition can develop due to

Options

A. Temporary increase in circulating estrogen in neonates
B. Temporary increase in circulating estrogen at puberty
C. Decreased testosterone in later life
D. All of these

Answer

### Step-by-Step Solution:

1. **Understanding Gynecomastia**:
- Gynecomastia is a condition characterized by the enlargement of breast tissue in males. This condition arises due to an imbalance between the levels of estrogen and testosterone in the body.

2. **Role of Estrogen and Testosterone**:
- Estrogen is a hormone that promotes the growth of breast tissue. In contrast, testosterone acts to inhibit this growth by suppressing the effects of estrogen. In normal circumstances, males have lower levels of estrogen and higher levels of testosterone, which prevents breast tissue development.

3. **Analyzing the Options**:
- **Option A**: Temporary increase in circulating estrogen in neonates.
- This is correct. Newborn males can experience a temporary rise in estrogen levels, leading to gynecomastia.
- **Option B**: Temporary increase in circulating estrogen at puberty.
- This is also correct. During puberty, hormonal changes can lead to increased estrogen levels, which may cause breast tissue enlargement.
- **Option C**: Decreased testosterone in later life.
- This statement is correct as well. As males age, testosterone levels may decline, reducing its ability to suppress estrogen, which can lead to gynecomastia.
- **Option D**: All of these.
- Since all previous options are correct, this option is also correct.

4. **Conclusion**:
- Since all the conditions mentioned can lead to the development of gynecomastia, the correct answer is **Option D: All of these**.