Which of the following is not caused by hyperactivity of endocrine gland ?

Options

A. Conn's syndrome
B. Cushing's syndrome
C. Addison's disease
D. Adrenal virilism

Answer

To determine which of the following conditions is not caused by hyperactivity of an endocrine gland, we will analyze each option provided in the question: Kohn's syndrome, Cushing's syndrome, Addison's disease, and Adrenal virilism.

### Step-by-Step Solution:

1. **Kohn's Syndrome**:
- Kohn's syndrome, also known as primary hyperaldosteronism, is characterized by the overproduction of aldosterone from the adrenal glands. This condition is indeed caused by hyperactivity of the adrenal gland.
- **Conclusion**: This is caused by hyperactivity.

2. **Cushing's Syndrome**:
- Cushing's syndrome is associated with excessive levels of cortisol in the body, which is also a result of hyperactivity of the adrenal glands. It is often referred to as hypercortisolism.
- **Conclusion**: This is also caused by hyperactivity.

3. **Addison's Disease**:
- Addison's disease is known as primary adrenal insufficiency, which means there is a deficiency or low production of adrenal hormones (like cortisol and aldosterone). This condition is characterized by hypoactivity of the adrenal glands.
- **Conclusion**: This is NOT caused by hyperactivity.

4. **Adrenal Virilism**:
- Adrenal virilism refers to the excessive production of androgens (male hormones) from the adrenal glands, leading to masculinization. This condition is a result of hyperactivity of the adrenal glands.
- **Conclusion**: This is caused by hyperactivity.

### Final Answer:
The condition that is not caused by hyperactivity of the endocrine gland is **Addison's disease**.

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