Which of the following is an auto-immune disorder in which the person produces antibodies that mimic the action of TSH, but are not regulated by the normal negative feedback controls?

Options

A. Myxoedema
B. grave's diseas
C. Cretinism
D. Hypocalcemic tetany

Answer

To solve the question regarding the autoimmune disorder where the person produces antibodies that mimic the action of TSH (Thyroid Stimulating Hormone) without normal negative feedback controls, we can follow these steps:

### Step-by-Step Solution:

1. **Understand Autoimmune Disorders**:
- Autoimmune disorders occur when the body's immune system mistakenly attacks its own cells. This means the immune system fails to distinguish between self and non-self cells, leading to damage.

2. **Identify the Role of TSH**:
- TSH is a hormone produced by the pituitary gland that stimulates the thyroid gland to release thyroid hormones (T3 and T4). These hormones are crucial for regulating metabolism.

3. **Understand Negative Feedback Mechanism**:
- Normally, when thyroid hormone levels are sufficient, they exert negative feedback on the pituitary gland to reduce TSH production. This helps maintain hormone levels within a normal range.

4. **Analyze the Question**:
- The question specifies an autoimmune disorder where antibodies mimic TSH. This means that these antibodies can stimulate the thyroid gland in a similar way to TSH, leading to increased production of thyroid hormones.

5. **Consider the Options**:
- **Myxedema**: This is associated with hypothyroidism, not hyperthyroidism.
- **Graves' Disease**: This is characterized by the presence of antibodies that stimulate the thyroid gland, leading to hyperthyroidism. It fits the description given in the question.
- **Cretinism**: This is also related to hypothyroidism, particularly in infants.
- **Hypocalcemic Technique**: This is related to calcium levels, not thyroid function.

6. **Conclusion**:
- Based on the analysis, the correct answer is **Graves' Disease**, as it is the autoimmune disorder where antibodies mimic TSH and lead to an increase in thyroid hormone production without the normal negative feedback regulation.

### Final Answer:
**Graves' Disease**