Eli Lilly an American company is famous for

Options

A. Producing GH (growth hormone) synthesised by recombinant DNA technology
B. Preparing two DNA sequences corresponding to A and B chains of human instJlin and introduced them in the plasmids of E. coli to produce insulin chains
C. Producing pest resistant plants, by RNA interference
D. Producing vitamin 'A' enriched rice

Answer

**Step-by-Step Solution:**

1. **Identify the Company**: Eli Lilly is an American pharmaceutical company known for its contributions to biotechnology and pharmaceuticals.

2. **Key Product**: The company is particularly famous for the production of Humulin, which is human insulin synthesized using recombinant DNA (rDNA) technology.

3. **Understanding rDNA Technology**: Recombinant DNA technology involves the isolation of specific genes and their insertion into plasmids, which are then introduced into bacteria (such as E. coli) to produce desired proteins.

4. **Production of Humulin**:
- **Gene Isolation**: The insulin-producing gene is isolated from the human pancreas, which consists of two chains known as the A and B chains.
- **Insertion into Plasmids**: These A and B chains are inserted into plasmids.
- **Transformation**: The plasmids containing the insulin gene are introduced into E. coli bacteria.
- **Protein Production**: The bacteria then use the inserted genes to produce human insulin, which is known as Humulin.

5. **Conclusion**: Eli Lilly was the first company to produce recombinant human insulin (Humulin) using this method, marking a significant advancement in biotechnology and diabetes treatment.

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