Which amongst glucose, amino acids fructose and chloride ions are generally not absorbed by simple diffusion?

Explanation

To determine which of the given substances (glucose, amino acids, fructose, and chloride ions) is generally not absorbed by simple diffusion, we need to analyze each substance based on their properties and the mechanism of absorption.

### Step-by-Step Solution:

1. **Understanding Simple Diffusion**:
- Simple diffusion is the process where molecules move across a semi-permeable membrane from an area of higher concentration to an area of lower concentration without the need for energy or transport proteins.

2. **Analyzing Glucose**:
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