Which of the following pairs is not correctly matched ?

Options

A. Vitamin `B_(12)` - Pernicious anaemia
B. Vitamin `B_(6)` - Loss of appetite
C. Vitamin `B_(1)` - Beri-beri
D. Vitamin `B_(1)` - Pellagra

Answer

To determine which of the following pairs is not correctly matched, we will analyze each option provided in the question:

1. **Vitamin B12 - Pernicious Anemia**
- Vitamin B12 deficiency leads to pernicious anemia, which is characterized by the inadequate production of red blood cells (RBCs). Symptoms include shortness of breath, chest pain, and numbness in hands and feet. This is a correct match.

2. **Vitamin B6 - Loss of Appetite**
- Vitamin B6 (also known as pyridoxine) deficiency can lead to various symptoms, including loss of appetite, malabsorption syndromes, and conditions like Crohn's disease and celiac disease. Therefore, this is also a correct match.

3. **Vitamin B1 - Beriberi**
- Vitamin B1, or thiamine, deficiency causes beriberi, which is characterized by symptoms such as weight loss, impaired sensory perception, emotional disturbances, and irregular heartbeat. This is a correct match as well.

4. **Vitamin B1 - Pellagra**
- Pellagra is caused by a deficiency of Vitamin B3 (niacin), not Vitamin B1. Therefore, this pairing is incorrect.

Based on the analysis, the pair that is not correctly matched is:

**Vitamin B1 - Pellagra**

### Summary of the Solution:
- **Correct Matches:**
- Vitamin B12 - Pernicious Anemia
- Vitamin B6 - Loss of Appetite
- Vitamin B1 - Beriberi
- **Incorrect Match:**
- Vitamin B1 - Pellagra (Correct disease is caused by Vitamin B3 deficiency)